Diagnostics & wearables
Biological age, inflammation, metabolic response, sleep, recovery, and food-specific glycemic / lipemic response. The 2026 doc's recurring point: every intervention is uncalibrated without a baseline and a feedback loop. No baseline currently established.
Biological age & inflammation
| Test | Provider | Method | What it measures | Indicative cost |
|---|---|---|---|---|
| TruAge COMPLETE | TruDiagnostic | DNA methylation, Illumina EPIC array (>900,000 CpG sites) | OMICmAge (Harvard, systemic risk), SYMPHONYAge (Yale, organ-specific), DunedinPACE (Duke/Columbia, real-time pace of aging). Plus telomere length, immune cell profiling. | ~£380 (UK) |
| GlycanAge | GlycanAge | IgG glycan analysis | Systemic immune-driven inflammation. Sensitive to diet, toxins, stress, exercise. | — |
| GrimAge | — | DNA methylation + plasma-protein proxies | Lifespan / mortality prediction. Legacy gold-standard now superseded by OMICmAge in most TruAge protocols. | — |
| Horvath Clock | — | DNA methylation, 353 CpG sites | The original 2013 multi-tissue clock. Foundational; less precise than modern algorithms. | — |
| myDNAge / epiAge | — | Targeted NGS methylation | Basic biological-age estimate. | — |
Recommended cadence: TruAge COMPLETE annually as the systemic baseline; GlycanAge bi-annually as an inflammatory checkpoint.
Continuous metabolic monitoring (CGM)
| Device | Notes |
|---|---|
| Abbott Lingo | Triceps-worn, up to 14 days. Tracks postprandial glucose. |
| Dexcom Stelo | OTC. Real-time glucose. |
CGM closes the feedback loop on Met4Min's glycemic role (see Supplements) and turns dietary guidance from generic to user-specific. Unchecked glucose spikes accelerate advanced glycation end-product (AGE) formation — degrades collagen, induces endothelial dysfunction, accelerates systemic aging.
Sleep, recovery, strain wearables
| Device | Form | Tracks |
|---|---|---|
| Oura Ring 4 | Ring | Sleep stages, HRV, readiness / recovery, temperature. |
| Garmin Vivoactive 6 | AMOLED smartwatch | Morning reports, VO₂ max, incident detection. |
| WHOOP | Strap | Strain, recovery, sleep. Pace of Aging algorithm. |
| Apple Watch SE 3 | Smartwatch | General health + fitness. ECG on higher-tier models. |
Female-specific wearables
| Device | Tracks |
|---|---|
| Vivoo FlowPad | Menstrual-fluid test — ovarian / hormonal indicators. |
| Peri | Perimenopausal symptom tracking. |
Personalised nutrition
| Product | Type | Notes |
|---|---|---|
| ZOE | App + home tests | Gut microbiome, blood transcriptome, glycemic / lipemic response. Largest personalised-nutrition study globally (30k+ participants). AI coach ("Ziggie") gives food scores; plant-diversity counter. |
| Daily30+ | Supplement (ZOE) | 30+ plant sources daily for microbiome diversity. |
ZOE pairs naturally with a CGM — the test-rich onboarding (CGM, blood, microbiome) establishes a metabolic phenotype, then the app gives meal-level recommendations against it.
UK longevity clinics & retreats
| Clinic | Location | Notes |
|---|---|---|
| Span Clinic | Online (physician-led) | Longevity diagnostics + intervention planning. Best fit for a remote-first relationship. |
| Hum2n Clinic | London | Medical-grade biohacking. |
| Vidavii | — | Breathe / Freeze / Squeeze flow circuits. |
| The Longevity Lounge at Cloud Twelve | London | Curated by Jenya Di Pierro. |
| Tranquil Waters Retreat | Nottinghamshire | HBOT, NeuroVizr, colonic irrigation, IV glutathione. |
| Nottingham Road Clinic | Mansfield | CQC-registered. Hosts Span Clinic. |
Gaps & open items
- No biological-age baseline. The single highest-leverage gap. TruAge COMPLETE (~£380) gates everything in Clinical compounds.
- No CGM. Cheapest data-rich win; closes the loop on Met4Min and informs ZOE.
- No sleep / HRV wearable. Oura Ring 4 is the lowest-friction option; WHOOP if performance metrics matter more.
- No personalised nutrition data (ZOE / Daily30+).
- No physician relationship at any UK clinic. Span (remote) is the lowest-cost first contact.